Publications

Refereed Publications (student authors underlined) 

  • Fahey JW, Liu H, Batt H, Panjwani AA, Tsuji PA. (2025) Sulforaphane and brain health: from pathways of action to effects on specific disorders. Nutrients 2025, 17(8), 1353. 
  • Bang J, Kang D, Jung J, Yoo TJ, Shim MS, Gladyshev VN, Tsuji PA, Hatfield DL, Kim JH, Lee BJ (2022). SEPHS1: Its evolution, function and roles in development and diseases. Archives of Biochemistry and Biophysics 730, 109426. 
  • Tsuji PA*, Santesmasses D, Lee BJ, Gladyshev VN, Hatfield DL (2021). Historical roles of selenium and selenoproteins in health and development: the good, the bad and the ugly. International Journal of Molecular Sciences 23(1),5.  
  • Canter JA, Ernst SE, Peters KM, Carlson BA, Thielman, NRJ, Grysczyk L, Udofe P, Yu Y, Cao L, Davis CD, Gladyshev VN, Hatfield DL, Tsuji PA* (2021). Selenium and the 15kDa selenoprotein impact colorectal tumorigenesis by modulating intestinal barrier integrity. International Journal of Molecular Sciences 22(19), 10651.  
  • Peters KM, Carlson BA, Gladyshev VN, Tsuji PA* (2018) Selenoproteins in colon cancer. Free Radic Biol Med 127:14-25. 
  • Yim SH, Everley RA, Schildberg FA, Lee SG, Orsi A, Barbati ZR, Karatepe K, Fomenko DE, Tsuji PA, Luo HR, Gygi SP, Sitia R, Sharpe AH, Hatfield DL, Gladyshev VN. (2018) Role of Selenof as a Gatekeeper of Secreted Disulfide-Rich Glycoproteins. Cell Reports. 23(5):1387-1398. 
  • Carlson BA, Lee BJ, Tsuji PA, Copeland PR, Schweizer U, Gladyshev VN, Hatfield DL. (2018) Selenocysteine tRNA[Ser]Sec, the Central Component of Selenoprotein Biosynthesis: Isolation, Identification, Modification, and Sequencing. Methods Mol Biol. 2018;1661:43-60. 
  • Carlson BA, Tobe R, Yefremova E, Tsuji PA, Hoffmann VJ, Schweizer U, Gladyshev VN, Hatfield DL, Conrad M. (2016) Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration. Redox Biology 9: 22-31. 
  • Gladyshev VN, Arnér ES, Berry MJ, Brigelius-Flohé R, Bruford EA, Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland PR, Diamond AM, Driscoll DM, Ferreiro A, Flohé L, Green FR, Guigó R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A, Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, Köhrle J, Krol A, Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV, Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP, Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U, Simonović M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD, Zhang Y. Selenoprotein gene nomenclature (2016). Journal of Biological Chemistry 291(46): 24036-24040. 
  • Tobe R, Carlson BA, Huh J, Castro C, Xu SM, Tsuji PA, Lee S, Bang J, Na JW, Kong YY, Beaglehole D, Southon E, Seifried H, Tessarollo L, Salomon D, Schweizer U, Gladyshev VN, Hatfield DL, and Lee B (2016). Selenophosphate Synthetase 1 is an Essential Protein with Roles in Regulation of Redox Homeostasis in Mammals. The Biochemical Journal 473(14): 2141-54 
  • Tobe R, Carlson BA, Tsuji PA, Lee BJ, Gladyshev VN, Hatfield DL (2015) Differences in Redox Regulatory Systems in Human Lung and Liver Tumors Suggest Different Avenues for Therapy. Cancers 7(4):2262-2276 
  • Tsuji PA*, Carlson BA, Anderson CB, Seifried HE, Hatfield DL, Howard MT* (2015). Dietary selenium levels affect selenoprotein expression and support the interferon-γ and IL-6 immune response pathways in mice. Nutrients 7(8), 6529-6549. 
  • Tsuji PA*, Carlson BA, Yoo M-H, Naranjo-Suarez S, Xu X, He Y, Asaki E, Seifried HE, Reinhold WC, Davis CD, Gladyshev VN, Hatfield DL (2015). The 15kDa selenoprotein and thioredoxin reductase 1 promote colon cancer by different pathways. PLoS One. 10(4):e0124487. 
  • Bang J, Huh JH, Na JW, Lu Q, Carlson BA, Tobe R, Tsuji PA, Gladyshev VN, Hatfield DL, Lee BJ (2015). Cell Proliferation and Motility are Inhibited by G1 Phase Arrest in 15-kDa Selenoprotein-Deficient Chang Liver Cells. Molecules and Cells 38(5):457-65. 
  • Bang J, Jang M, Huh JH, Na JW, Shim M, Carlson BA, Tobe R, Tsuji PA, Gladyshev VN, Hatfield DL, Lee BJ (2015). Deficiency of the 15-kDa selenoprotein led to cytoskeleton remodeling and non-apoptotic membrane blebbing through a RhoA/ROCK patway. Biochemical and Biophysical Research Communications 456(4):884-90. 
  • Hatfield DL, Tsuji PA, Carlson BA and Gladyshev VN (2014). Selenium and selenocysteine: Roles in cancer, health and development. Trends in Biochemical Sciences, 39(3):112-120 (also featured on the cover of the journal issue). 
  • Tsuji PA, Stephenson KK, Wade KL, Liu H and Fahey JW (2013). Structure-activity analysis of flavonoids: direct and indirect antioxidant, and anti-inflammatory potencies and toxicities. Nutrition and Cancer: An International Journal, 65(7): 1014-1025. 
  • Naranjo-Suarez S, Carlson BA, Tobe R, Yoo MH, Tsuji PA, Gladyshev VN and Hatfield DL (2013). Regulation of HIF-1α Activity by Overexpression of Thioredoxin is Independent of Thioredoxin Reductase Status. Molecules and Cells, 36(2): 141-157. 
  • Tobe R, Naranjo-Suarez S, Everley RA, Carlson BA, Turanov AA, Tsuji PA, Yoo MH, Gygi SP, Gladyshev VN and Hatfield DL (2013). High error rates in selenocysteine insertion in mammalian cells treated with the antibiotics, doxycycline, chloramphenicol or geneticin. Journal of Biological Chemistry  288(21): 14709-14715 
  • Tsuji PA, Carlson BA, Naranjo-Suarez S, Yoo M-H, Xu XM, Fomenko D, Gladyshev VN, Hatfield DL and Davis CD (2012). Knockout of the 15 kDa selenoprotein protects against chemically-induced aberrant crypt formation in mice PLoS One 7(12):e50574. 
  • Naranjo-Suarez S, Carlson BA, Tsuji PA, Yoo M-H, Gladyshev VN and Hatfield DL. (2012). HIF-independent regulation of thioredoxin reductase 1 contributes to the high levels of reactive oxygen species induced by hypoxia. PLoS ONE 7:e03470 
  • Davis CD, Tsuji PA and Milner JA (2012). Selenoproteins and cancer prevention. Annual Reviews of Nutrition 32:73-95 
  • Tsuji PA, Naranjo-Suarez S, Carlson BA, Tobe R,  Yoo M-H and Davis CD (2011).  Deficiency in the 15 kDa selenoprotein inhibits human colon cancer cell growth. Nutrients, 3(9): 805-817. 
  • Kasaikina M, Fomenko D, Labunskyy V, Lachke S, Qiu W, Moncaster J, Shang J, Wojnarowicz M, Kumar S, Malinouski M, Schweizer U, Tsuji PA, Carlson BA, Maas R, Lou M, Goldstein L, Hatfield DH and Gladyshev VN (2011). 15 kDa selenoprotein (Sep15) knockout mice reveal roles of Sep15 in redox homeostasis and cataract development. Journal of Biological Chemistry, 286(38): 33203-12. 
  • Yoo M-H, Carlson BA, Tsuji PA, Irons RI, Gladyshev VN and Hatfield DL (2010) Alteration of thioredoxin reductase 1 levels in elucidating cancer etiology. Methods in Enzymology, 474: 255-275 
  • Irons RI, Tsuji PA, Carlson BA, Ouyang P, Yoo MH, Xu XM, Hatfield DL, Gladyshev VN, and Davis CD. (2010) Deficiency in the  15 kDa selenoprotein (Sep15) inhibits tumorigenicity and metastasis of colon cancer cells. Cancer Prevention Research, 3(5):630-639. (first co-author) 
  • Carlson BA, Yoo MH, Tsuji PA, Gladyshev VN and Hatfield DL. (2009)  Mouse models targeting selenocysteine tRNA expression for elucidating the role of selenoproteins in health and development. Molecules 14(9):3509-27 
  • Tsuji PA and Walle T (2008) Cytotoxic effects of the dietary flavones chrysin and apigenin in a normal trout liver cell line. Chemico-Biological Interactions, 171: 37-44 
  • Walle T, Ta N, Kawamori T, Wen X, Tsuji PA and Walle UK (2007). Cancer chemopreventive properties of orally bioavailable flavonoids – Methylated versus unmethylated flavones. Biochemical Pharmacology, 73(9):1288-1296 
  • Tsuji PA and Walle T (2007) Benzo[a]pyrene-induced cytochrome P4501A and DNA binding in cultured trout hepatocytes-Inhibition by plant polyphenols. Chemico-Biological Interactions, 169(1): 25-31 
  • Tsuji PA, Winn RN and Walle T (2006) Accumulation and metabolism of the anticancer flavonoid 5,7-DMF compared to its unmethylated analog chrysin in the Atlantic killifish. Chemico-Biological Interactions, 164:85-92 
  • Tsuji PA and Walle T (2006) Inhibition of benzo[a]pyrene-activating enzymes and DNA binding in human bronchial epithelial BEAS-2B cells by methoxylated flavonoids. Carcinogenesis, 27(8):1579-1585  

 

Book Chapters (TU graduate & undergraduate students underlined) 

  • Tsuji PA* and Hatfield DL (2022). Editorial to Special Issue Molecular Biology of Selenium in Health and Disease. International Journal of Molecular Sciences 23(2), 808. https://doi.org/10.3390/ijms23020808  
  • 硒：分子生物学与人体健康. 北京: 科学出版 2018. (Selenium: Its molecular biology and role in human health; Eds. Hatfield, D.L., Schweizer, U., Tsuji, P.A. and Gladyshev, V.N. Originally: Springer Science+Business Media, LLC, New York, NY, 2016. (See reference 2-5 below) was translated into Chinese (Mandarin). Edited by Lei, X.G. (雷新根) and Wang F.（王福俤) ISBN: 978-7-03-057799-3. 
  • Peters KM, Galinn SE, and Tsuji PA* (2016). Selenium: Dietary sources, human nutritional requirements and intake across populations. In Selenium: Its molecular biology and role in human health. (4th Edition) Hatfield DL, Schweizer U, Tsuji PA, Gladyshev VN, Editors. Springer Science+Business Media, LLC, New York, NY. 
  • Carlson BA, Hartman JM, and Tsuji PA* (2016). The 15kDa selenoproteins: Insights into its regulation and function. In Selenium: Its molecular biology and role in human health. (4th Edition) Hatfield DL, Schweizer U, Tsuji PA, Gladyshev VN, Editors. Springer Science+Business Media, LLC, New York, NY. 
  • Tsuji PA*, Carlson BA, Lee BJ, and Hatfield DL (2016). Interplay of selenoproteins and different antioxidant systems in various cancers. In Selenium: Its molecular biology and role in human health. (4th Edition) Hatfield DL, Schweizer U, Tsuji PA, Gladyshev VN, Editors. Springer Science+Business Media, LLC, New York, NY. 
  • Carlson BA, Lee BJ, Tsuji PA, Tobe R, Park JM, Schweizer U, Gladyshev VN, and Hatfield DL (2016). Selenocysteine tRNA[Ser]Sec: From nonsense suppressor tRNA to the quintessential constituent in selenoprotein biosynthesis. In Selenium: Its molecular biology and role in human health. (4th Edition) Hatfield DL, Schweizer U, Tsuji PA, Gladyshev VN, Editors. Springer Science+Business Media, LLC, New York, NY. 
  • Galinn SE and Tsuji PA*. Quercetin and kaempferol ameliorate inflammation through Nrf2 and other signaling pathways (2016). In Broccoli: Cultivation, Nutritional Properties and Effects on Health. Juurlink B, Editor. Nova Publishers, Hauppauge, NY. 
  • Canter JA, Rosso LE, and Tsuji PA*. Trace Minerals. (Nov. 2015) In Encyclopedia of Food and Health. Caballero, Finglas, Toldrá, Editors. Elsevier, Oxford, UK. 
  • Galinn SE, Hartman J, and Tsuji PA*. Diet and Cancer. (Nov. 2015) In Encyclopedia of Food and Health. Caballero, Finglas, Toldrá, Editors. Elsevier, Oxford, UK. 
  • Carlson BA, Tobe R, Tsuji PA, Yoo MH, Feigenbaum L, Tessarollo L, Lee BJ, Schweizer U, Gladyshev VN, Hatfield DL. (Aug. 2015) Selenocysteine tRNA[Ser]Sec: The central component of selenoprotein biosynthesis. In Diversity of selenium functions in health and disease. CRC Press. Brigelius-Flohé R, Sies H, Editors. CRC Press, Taylor & Francis Group, Boca Raton, FL 
  • Tsuji PA* and Davis CD (2015). U-shaped functions of selenoproteins in cancer: The 15-kDa Selenoprotein (Sep15). In Diversity of selenium functions in health and disease. Brigelius-Flohé R, Sies H, Editors. CRC Press, Taylor & Francis Group, Boca Raton, FL 
  • Tsuji PA*, Davis CD and Milner JA (2012). Selenium: Dietary sources and human requirements. In Selenium: Its molecular biology and role in human health. (3rd Edition) Hatfield DL, Berry MJ, Gladyshev VN, Editors. Springer Science+Business Media, LLC, New York, NY. 
  • Yoo M-H, Carlson BA, Tsuji PA, Tobe R, Naranjo-Suarez S, Lee BJ, Davis CI, Gladyshev VN and Hatfield DL (2012). Selenoproteins harboring a split personality in both preventing and promoting cancer. In Selenium: Its molecular biology and role in human health. (3rd Edition) Hatfield DL, Berry MJ, Gladyshev VN, Editors. Springer Science+Business Media, LLC, New York, NY.  
  • Carlson BA, Yoo M-H, Tsuji PA, Tobe R, Naranjo-Suarez S, Chen F, Xu X-M, Feigenbaum L, Tesserrollo L, Lee, BJ, Gladyshev VN and Hatfield DL (2012). Mouse models that target removal or over-expression of the selenocysteine tRNA[Ser]Sec gene to elucidate the role of selenoproteins in health and development. In Selenium: Its molecular biology and role in human health. (3rd Edition) Hatfield DL, Berry MJ, Gladyshev VN, Editors. Springer Science+Business Media, LLC, New York, NY. 
  • Tsuji PA* and Carlson BA (2012). Selenoprotein Sep15. Encyclopedia of Metalloproteins. Kretsinger RH, Uversky VN, Permyakov EA, Editors. Springer Science+Business Media, LLC, New York, NY.