Elana S. Ehrlich
8000 York Rd, Towson, MD 21252
PHONE: 410-704-2385
FAX: 410-704-2405
Professional Preparation:
University of Massachusetts Biology BS 2001
Johns Hopkins University Molecular Microbiology and Immunology Ph.D. 2007
Johns Hopkins University Viral Oncology postdoctoral fellow 2008-2011
Appointments:
Associate Professor, Towson University 2017-present
Assistant Professor, Towson University 2011-2017
Research positions:
Post Doctoral Fellow, Johns Hopkins University School of Medicine 2008-2011
Doctoral student, Johns Hopkins University Bloomberg School of Public Health 2002-2008
Lab Technician, Tufts University School of Medicine 2000-2001
Intern, Schepens Eye Research Institute, Harvard Medical School 1999-2000
Teaching positions:
Assistant Professor of Biology, Towson University, Towson, MD 2011-present
Adjunct Professor of Biology, Stevenson University, Baltimore, MD 2009-2010
Teaching Assistant, Johns Hopkins University, Bloomberg School of Public Health,
Baltimore, MD – Advanced Topics in AIDS Research 2007
Genetics Tutor, University of Massachusetts, Boston, MA 1998-1999
Peer-reviewed publications:
Jennifer Chmura**, Kevin Herold**, Ayana Ruffin**, Trudymae Atuobi**, Ashley Mitchell**, and Elana Ehrlich. The Itch ubiquitin ligase is required for KSHV RTA induced vFLIP degradation. 2016. Virology. 2017 Jan 15;501:119-126. doi: 10.1016/j.virol.2016.11.016. PMID: 27912080
Wenyan Zhang, Zhaolong Li, Jinghua Yu, Zhenhong Wei, Elana S. Ehrlich, Xin Liu, Jingliang L, Hong Wang, and Xiaofang Yu. Coxsackievirus A16 infection Induces Neural Cell and non-Neural Cell Apoptosis in vitro. PLoS One. 2014. PLoS One. 2014 Oct 28;9(10) PMID:25350381
Elana S. Ehrlich, Jennifer C. Chmura**, John C. Smith*, Nene Kalu and Gary S. Hayward. KSHV RTA abolishes NFĸB responsive gene expression during lytic reactivation by targeting vFLIP for degradation via the proteasome. PLoS One. 2014 Mar 10;9(3) PMID: 24614587
Elana S. Ehrlich, Tao Wang, Kun Luo, Zuoxiang Xiao, Anna Maria Niewiadomska, Tara Martinez, Wanping Xu, Len Neckers and Xiao-Fang Yu. Regulation of Hsp90 client proteins by a Cullin5-RING E3 ubiquitin ligase. Proc Natl Acad Sci U S A. 2009 Nov 20.
Sumithra Jayaram, Timra Gilson, Elana S. Ehrlich, Xiao-Fang Yu, Gary Ketner and Les Hanakahi. E1B 55k-independent dissociation of the DNA ligase IV/XRCC4 complex by E4 34k during adenovirus infection. Virology. 2008 Dec 20;382(2):163-70.
Bradford J. Stanley, Elana S. Ehrlich, Leslie Short, Yunkai Yu, Zuoxiang Xiao, Xiao-Fang Yu, Yong Xiong, Structural Insight into the HIV Vif SOCS Box and Its Role in Human E3 Ubiquitin Ligase Assembly J Virol. 2008 Jun 18
Zuoxiang Xiao, Yong Xiong, Wenyan Zhang, Lindi Tan, Elana Ehrlich, Deyin Guo, Xiao-Fang Yu. Characterization of a Novel Cullin5 Binding Domain in HIV-1 Vif. J Mol Biol. 2007 Oct 26;373(3):541-50.
Lindi Tan, Elana Ehrlich, Xiao-Fang Yu. DDB1 and Cul4A are required for HIV-1 Vpr-induced G2 arrest. J Virol. 2007 Jul 11
Kun Luo, Elana Ehrlich, Zuoxiang Xiao, Wenyan Zhang, Gary Ketner, Xiao-Fang Yu. Adenovirus E4orf6 assembles with Cullin5-ElonginB-ElonginC E3 ubiquitin ligase through an HIV/SIV Vif-like BC-box to regulate p53. FASEB J. 2007 Mar 9
Zuoxiang Xiao, Elana Ehrlich, Kun Luo, Yong Xiong, Xiao-Fang Yu. Zinc chelation inhibits HIV Vif activity and liberates antiviral function of the cytidine deaminase APOBEC3G. FASEB J. 2007 Jan;21(1):217-22.
Zuoxiang Xiao, Elana Ehrlich, Yunkai Yu, Kun Luo, Tao Wang, Chunjuan Tian and Xiao-Fang Yu. “Assembly of HIV-1 Vif-Cul5 E3 ubiquitin ligase through a novel zinc-binding domain-stabilized hydrophobic interface in Vif.” Virology. 2006 Mar 10
Elana Ehrlich and Xiao-Fang Yu. Lentiviral Vif: viral hijacker of the ubiquitin-proteasome system. Int J Hematol. 2006 Apr;83(3):208-12. Review. PMID:16720549
Kun Luo, Zuoxiang Xiao, Elana Ehrlich, Yunkai Yu, Bindong Liu, Shu Zheng, and Xiao-Fang Yu. “Primate lentiviral virion infectivity factors are substrate receptors that assemble with cullin 5–E3 ligase through a HCCH motif to suppress APOBEC3G”. Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11444-9.
Yunkai Yu, Zuoxiang Xiao, Elana S. Ehrlich, Xianghui Yu and Xiao-Fang Yu. “Selective assembly of HIV-1 Vif-Cul5-ElonginB-ElonginC E3 ubiquitin ligase complex through a novel SOCS box and upstream cysteines”. GENES & DEVELOPMENT 18:2867-2872, 2004.
Florence Boisgérault, Ying Liu, Natalie Anosova, Elana Ehrlich, M. Reza Dana and Gilles Benichou. “Role of CD4+ and CD8+ T Cells in Allorecognition: Lessons from Corneal Transplantation” The Journal of Immunology, 2001, 167: 1891-1899.
Fellowships and Awards:
Jess & Mildred Fisher Endowed Chair in the Biological and Physical Sciences. 2014
The University System of Maryland Women’s Forum Faculty Research Award 2013
Anti-Cancer Drug Development Training Program Post Doctoral Fellowship (T32) 2008-10
Young Investigator Travel Grant – Conference on Retroviruses and Opportunistic Infections 2005,2006
Delta Omega Public Health Honor Society Poster Competition-First Place 2005
Fellow – Ronald E. McNair Post baccalaureate Achievement Program 1998-2001
Presentations:
2015, 2016 Annual Biomedical Research Conference for Minority Students
2014 American Society for Cell Biology
2014 Colonial Academic Alliance Undergraduate Research Conference*
2014 American Society for Microbiology**
2013,14,16 American Society for Virology**
2013,2014 Towson University Graduate and Undergraduate Research Expo*, **
2013,2014 Towson University Honors Convocation Research Poster Session*
2013,2014 Annual Undergraduate Research Symposium in the Chemical and Biological Sciences, University of Maryland, Baltimore County*
2013 16th International Workshop on Kaposi’s Sarcoma Herpesvirus (KSHV) and Related Agents**
2007 Cold Spring Harbor Ubiquitin Conference
2007 Cold Spring Harbor Retroviruses Conference
2005, 2006 Conference on Retroviruses and Opportunistic Infections
Funding:
2016 NIH 1R15GM118011-01 – “Ubiquitin and Ubls in KSHV” – Awarded $353,000 over three years.
2014 Fisher Endowed Chair, Fisher Foundation – “Improving breast cancer treatment: How gene expression influences sensitivity to chemotherapy”
2014 Faculty Development and Research Committee Grant – “Improving breast cancer treatment: How gene expression influences sensitivity to chemotherapy”
2013 PI on Bridges to the Baccalaureate Program grant– NIH funded R25
“Facilitating Seamless Transitions From Community College To Towson
University”, Project number: 2R25GM058264-10
2013 FCSM Undergraduate Research Grant – “Analysis of Cullin 5 Expression in Breast Cancer” awarded to Sarah Wicks*
2013 Towson University Undergraduate Research Grant – “Analysis of Cullin 5 Expression in Breast Cancer” awarded to Sarah Wicks*
2013 FCSM Undergraduate Research Grant – “Analysis of Cytomegalovirus (CMV) mutation in US28 and enhanced binding affinity of viruses to the mutant strain compared to wild-type” awarded to Laura Kretzer*
2013 The University System of Maryland Women’s Forum Faculty Research Award
2013 Fisher funds awarded for – Development of a Project-based Cell Biology Laboratory Course (with Michelle Snyder and Amy Trauth-Nare)
2013 Jess and Mildred Fisher Seed Funding
2012 Faculty Development and Research Committee Grant – “Activation of cellular signaling pathways by Kaposi’s sarcoma herpesvirus”
2012 Undergraduate Research Grant – “Analysis of Circulating Strains of Cytomegalovirus (CMV) in Mali” awarded to Sarah Wicks*
Teaching:
Towson University:
BIOL 408/508 Cell Biology (Fall semesters) 2011-present
BIOL 409 Molecular Biology (Spring semesters) 2012-2015
BIOL 490/491 Independent Research 2012-present
BIOL 481 Directed Reading in Biology 2012
HONR 497 Honors independent investigation 2012
BIOL 499 Honors Senior Thesis 2014
BIOL 703 Independent Study 2013
BIOL 797 Graduate Seminar 2016-2017
BIOL 896 Biology Thesis 2013-present
Stevenson University:
Microbiology 2009-2010
Service:
Professional Service and Activities:
Co-director Bridges to the Baccalaureate program 2016-present
Board Member – Creative City Public Charter School Foundation 2014-present
Invited Keynote Speaker – UMASS Boston McNair Graduation Ceremony 2013
Mentor – The Catholic High School of Baltimore STEM Mentoring Program 2012-2013
Panelist for Careers Workshop – Association for Women in Science 2012
Panelist for Careers Series – Johns Hopkins University 2012
Thesis Advisor:
Sarah Talamantez-Lyburn 2016-present
Deirdre Johnson 2016-present
Eisha Clyde 2016-present
Ayana Ruffin 2015-present
Kevin Herold 2014-2016
Jennifer Chmura 2012-2014
Non-thesis Graduate Research Advisor:
Yetunde Fabiyi 2015-2016
Trudymae Atuobi 2014-2016
Ashley Mitchell 2013-2015
Memberships:
American Society for Virology 2012-present
American Society for Cell Biology 2011-present
The Association for Women in Science 2012-present